Investigation of aquaporins and apparent diffusion coefficient from ultra-high b-values in a rat model of diabetic nephropathy

European Radiology Experimental

Table 4 Correlation between apparent diffusion coefficients (ADCs) and aquaporin-2 (AQP-2) in diabetes mellitus (DM) animals at four anatomical layers of the kidney

Position	AQP	ADC_low		ADC_st		ADC_uh
Position	AQP	r	p	r	p	r	p
CO	AQP-1	−0.123	ns 0.509	0.026	ns 0.890	−0.023	ns, 0.903
	AQP-2	−0.178	ns 0.346	−0.044	ns 0.871	0.427	ns, 0.018
	AQP-4	−0.109	ns 0.565	−0.098	ns 0.607	−0.174	ns, 0.358
OS	AQP-1	0.123	ns 0.516	0.141	ns 0.458	−0.157	ns, 0.407
	AQP-2	−0.280	ns 0.134	−0.047	ns 0.806	0.598	0.000
	AQP-4	−0.193	ns 0.306	−0.139	ns 0.464	−0.194	ns, 0.304
IS	AQP-1	−0.266	ns 0.155	−0.106	ns 0.576	−0.026	ns, 0.893
	AQP-2	−0.277	ns 0.138	−0.139	ns 0.464	0.490	0.006
	AQP-4	−0.073	ns 0.700	−0.036	ns 0.850	0.140	ns, 0.460
IM	AQP-1	0.175	ns 0.355	0.293	ns 0.115	−0.039	ns, 0.838
	AQP-2	−0.109	ns 0.567	0.003	ns 0.986	0.451	0.012
	AQP-4	0.141	ns 0.459	0.173	ns 0.362	−0.227	ns, 0.227

The r and p values were obtained using Pearson’s correlation analysis. DM diabetes mellitus, DM diabetes mellitus, CO cortex, OS outer stripe of the outer medulla, IS inner stripe of the outer medulla, IM inner medulla ns, not significant. Based on Bonferroni’s correction, p < 0.017 (0.05/3 tests) was considered to indicate a statistically significant difference