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Fig. 2 | European Radiology Experimental

Fig. 2

From: Investigation of aquaporins and apparent diffusion coefficient from ultra-high b-values in a rat model of diabetic nephropathy

Fig. 2

Immunocytochemical analysis of aquaporins (AQPs) on four different anatomical layers of the kidney. No difference was found between the group of streptozotocin-induced diabete mellitus (DM) animals (a-d) and the control group (e-h) in their AQP-1 expression on different anatomical layers of the kidney. Labeled AQP-1 was observed in the proximal tubules and Henle’s loops. The most intense labeling was found in the cortex and in the outer stripe of the outer medulla (a, b and e, f) in both groups. Labeled AQP-2 was observed on the apical plasma membrane and in intracellular cytoplasm domains. The labeling was the most intense in the outer stripe of the outer medulla (j and n). There was a noticeable increase in the AQP-2 labeling in OS, IS and IM in DM animals (j-l) compared with control animals (n-p). There was no significant difference between the tow group in there AQP-2 expression in CO (i and m). There was no significant difference between DM group (q-t) and control group (u-x) in their AQP-4 expression on different anatomical layers of the kidney. AQP-4 was detected in the collecting ducts and the proximal tubules. AQP-4 labeling was most intense in the inner medulla (t and x). Magnification × 400

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