Radiologic-pathologic correlation in breast cancer: do MRI biomarkers correlate with pathologic features and molecular subtypes?

European Radiology Experimental

Table 2 Association between breast cancer grading (high grade) and magnetic resonance imaging features

		High grade	χ2 analysis p-value	Univariate analysis		Multivariate analysis
				OR (CI 95%)^b	p-value	OR (CI 95%)^b	p-value
No. of patients		73
Tumour size	Median (mm) Range (mm)	52 34–75
≥ 2 cm		44/73	0.097	1.779 (0.899–3.518)	0.098
T2 intensity	Hypointensity Isointensity Hyperintensity	35/73 16/73 22/73	0.047^a	1.842 (0.918–3.697) 0.399 (0.189–0.844) 1.267 (0.595–2.699)	0.086 0.016 0.539	0.385 (0.124–1.193)	0.098
Mass enhancement		55/73	0.921	1.040 (0.478–2.264)	0.921
Rim enhancement		25/55	0.002	4.062 (1.607–10.271)	0.003	3.689 (1.011–3.467)	0.048
Intralesional necrosis		33/73	0.028	2.232 (1.084–4.597)	0.029	0.651 (0.193–2.195)	0.489
Perilesional oedema		45/73	0.001	3.214 (1.588–6.505)	0.001	2.105 (0.729–6.078)	0.169
Axillary adenopathy		32/73	0.008	2.732 (1.287–5.799)	0.009	2.241 (0.769–6.536)	0.139
Intensity-to-time curve	Type I Type II Type III	2/73 21/73 50/73	0.245	0.268 (0.052–1.377) 1.093 (0.515–2.319) 1.250 (0.613–2.548)	0.115 0.817 0.539
ADC value	Very low Low Intermediate	41/60 18/60 1/60	0.036^a	2.937 (1.385–6.228) 0.339 (0.159–0.723) 0.873 (0.053–14.29)	0.005 0.005 0.924	2.191 (0.806–5.951)	0.124
Extent of disease	Unifocal Multifocal Multicentric	29/73 27/73 17/73	0.011	0.494 (0.249–0.980) 3.522 (1.504–8.246) 0.759 (0.351–1.640)	0.044 0.004 0.483	2.247 (0.771–6.548)	0.138

^aBonferroni’s post hoc analysis found no significance. ^bOR Odds ratio, CI Confidence interval, ADC Apparent diffusion coefficient